Which inpatient CAP regimen combines a cephalosporin with doxycycline?

Which inpatient CAP regimen combines a cephalosporin with doxycycline?

• A. Ceftriaxone + Doxycycline
• B. IV Levofloxacin
• C. Azithromycin
• D. Amoxicillin

Answer: (A)

Inpatient CAP regimens are aimed at covering both typical bacteria (like Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis) and atypical pathogens (such as Mycoplasma and Chlamydophila). A cephalosporin provides solid coverage against the typical organisms, and adding doxycycline supplies reliable activity against the atypicals. The combination of a cephalosporin, such as ceftriaxone, with doxycycline therefore gives broad, in-hospital coverage suitable for hospitalized patients with CAP. The other options don’t fit this specific pairing: a fluoroquinolone like IV levofloxacin is a single agent with broad activity rather than a cephalosporin plus doxycycline; azithromycin is a macrolide and doesn’t pair with a cephalosporin in this regimen; amoxicillin alone is a beta-lactam but lacks reliable atypical coverage and is more typical of outpatient therapy.

Inpatient CAP regimens are aimed at covering both typical bacteria (like Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis) and atypical pathogens (such as Mycoplasma and Chlamydophila). A cephalosporin provides solid coverage against the typical organisms, and adding doxycycline supplies reliable activity against the atypicals. The combination of a cephalosporin, such as ceftriaxone, with doxycycline therefore gives broad, in-hospital coverage suitable for hospitalized patients with CAP.

The other options don’t fit this specific pairing: a fluoroquinolone like IV levofloxacin is a single agent with broad activity rather than a cephalosporin plus doxycycline; azithromycin is a macrolide and doesn’t pair with a cephalosporin in this regimen; amoxicillin alone is a beta-lactam but lacks reliable atypical coverage and is more typical of outpatient therapy.